The Cunning is tribute. It is not used, crafted with, or consumed by anything else in the game — its only purpose is opening an arena door.
Dragon Arena on
The Island, Ragnarok, Valguero, Fjordur
Dinopithecus King Arena on
Lost Island
Crystal Wyvern Queen Arena on
Crystal IslesOne artifact opens the portal once. Bring a spare if you intend to run the fight twice.
Alpha Megalodon, 
Ammonite, 
Angler, Cnidaria, 
Dunkleosteus, 
Electrophorus, Eurypterid, 
Manta, Megalodon, 
Mosasaur, 
Piranha, 
Plesiosaur, 
Trilobite, 
Tusoteuthis 
Ammonite, Anglerfish, 
Araneo, 
Arthropluera, Cnidaria, 
Coelacanth, 
Dung Beetle, Dunkleosteus, Electrophorus, Eurypterid, 
Helicoprion, Manta, Megalodon, Mosasaurus, Piranha, 
Pulmonoscorpius, 
Sabertooth Salmon, 
Titanoboa, Trilobite, 
Xiphactinus 
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Ankylosaurus
Argentavis
Dire Bear
Kairuku
Mammoth
Megaloceros
Woolly Rhino
Megalania
Megalosaurus
Onyc